Application of Phthalimide N-Sulfonic Acid as a Highly Efficient Catalyst for the Multicomponent reaction of Dimedone with Arylaldehydes, β-Ketoesters and Ammonium Acetate

Document Type : Research Paper

Authors

1 Phd Student of Chemistry, Payame Noor University, Iran.

2 Associate Professor of Organic Chemistry, Payame Noor University, Iran.

Abstract

In recent years, development of heterogeneous, easily recyclable and environmentally benign catalysts for synthesis of fine chemicals has attracted much attention. Solid acids are certainly an important class of the above-mentioned catalysts which have been used to promote different organic transformations. Catalytic activity of solid acids depends on their strength and number of acidic sites, and Lewis/Brønsted acidity. The advantages of application of solid acid catalysts in organic synthesis can summarize as follow: product isolation is simplified, reaction often performs under milder conditions, reaction selectivity often increases, atom efficiency of reaction is improved, the process is simplified, precious raw materials used for preparation of the catalysts are given increased lifetime (through reuse), volume of waste is significantly reduced, and process is in agreement with the green chemistry protocols. In this work, solid acid phthalimide N-sulfonic acid has been utilized as a highly efficient, heterogeneous and green catalyst for the one-pot multi-component condensation of dimedone with arylaldehydes, β-ketoesters and ammonium acetate under solvent-free conditions to afford polyhydroquinolines in excellent yields and in short reaction times.

Keywords

References

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History

  • Receive Date: 25 May 2017
  • Revise Date: 31 May 2017
  • Accept Date: 07 June 2017

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