Synthesis of Nano-Silica Sulfamic Acid-Catalyzed Dihydropyran Derivatives in Water Solvent and Ambient Temperature

Document Type : Research Paper

Authors

Department of Chemistry, Payame Noor University (PNU), P.O.Box 19395-4697, Tehran, Iran

Abstract

Minor reactions are a great tool in combination chemistry. Many of the principles of green chemistry, such as water solubility, high selectivity, low response time, high yields, lack of peripheral products in the production of compulsive compounds of the ring Observe oxygenate. Accordingly, the synthesis of dihydropyrid derivatives was accomplished by a few-step reaction, water solvent, using various aldehydes in the presence of heterogeneous nano-silica sulfamic acid catalyst at ambient temperature. The benefits of this high-efficiency synthesis of reaction, short time, operation simplicity, and catalyst recovery without significantly reducing its catalytic ability. Dihydropyran derivatives have been considered by demonstrating several biological properties such as anticonvulsant, diuretic, anticoagulant, anti-cancer,anti-HIV and important pharma-ological activity. In this project, The synthesis of these derivatives has been investigated through a multi-component condensation reaction.

Keywords

References

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Semiannual Organic Chemistry Journal
Volume 1, Issue 2
October 2022
Pages 71-81

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History

  • Receive Date: 25 January 2020
  • Revise Date: 29 September 2022
  • Accept Date: 23 July 2022

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